Long-term efficacy of GPi DBS for craniofacial dystonia: a retrospective report of 13 cases

• DOI: 10.1007/s10143-021-01584-4
• Publication Date: 2021-06-29T04:02:35Z
• Authors: Haibo Ren; Rong Wen; Wei Wang; Denghui Li; Mengqi Wang; Yuan Gao; Yang Xu; Yang Wu
• Keywords: Refractory (planetary science)

This study evaluated the long-term efficacy of globus pallidus internus (GPi) deep brain stimulation (DBS) in treatment craniofacial dystonia (Meige syndrome) and investigated correlation between volume tissue activated (VTA) GPi each subregion movement score improvement. We retrospectively analyzed clinical data 13 patients with drug-refractory Meige syndrome who were treated DBS. The pre- postoperative Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) scores compared. relationships preoperative baseline variables improvement BFMDRS-Movement (BFMDRS-M) analyzed. LEAD-DBS software was used for three-dimensional reconstruction implanted electrodes. correlations GPi-VTA average follow-up period 36.6 ± 11.0 months (18–55 months). At 3 after final visit, improvements BFMDRS-M 58.2 54.6%, BFMDRS-Disability (BFMDRS-D) 53.6 51.7%, respectively. eye, mouth, speech/swallowing significant (P < 0.001). Age an independent predictor DBS = 0.005). A decrease significantly positively correlated (r 0.757, P 0.003). is effective method treating syndrome. can be as aid visualization programming