Opioid-induced constipation in patients with cancer pain in Japan (OIC-J study): a post hoc subgroup analysis of patients with gastrointestinal cancer

• DOI: 10.1007/s10147-020-01790-y
• Publication Date: 2020-10-17T07:03:16Z
• Authors: Toshiyuki Harada; Hisao Imai; Soichi Fumita; Toshio Noriyuki; Makio Gamoh; Masaharu Okamoto; Yusaku Akashi; Yoshiyuki Kizawa; Akihiro Tokoro
• Keywords: Post-hoc analysis; Surgical oncology; Subgroup analysis

Abstract Background Constipation is a common side effect of opioid therapy. An observational study opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 various tumor types. This post hoc analysis OIC-J evaluated subgroup gastrointestinal (GI) cancer. Methods Patients were aged ≥ 20 years, starting strong therapy, had an ECOG PS ≤ 2, and must have 3 bowel movements during the week before enrollment. OIC was for 2 weeks after initiation using Rome IV diagnostic criteria colorectal disorders, as well physician’s diagnosis, number spontaneous movements, Bowel Function Index score, patient’s self-assessment. Relationships between baseline characteristics incidence, effects on quality life (QOL) also explored. Results Fifty from who GI [colon (50%), stomach (28%), esophageal (22%)] included. incidence varied by which used (46.0–62.0%) occurred rapidly initiating The use prophylactic laxatives reduced overall rate 71.0% to 47.4%. No characteristics, except comorbidities, associated incidence. Change day 15 PAC-SYM total score significantly greater versus those without (0.188 −0.362; P = 0.0011). Conclusions suggests that occurs negatively impacts QOL. Early effective intervention strategies may be particularly useful this group. Additional Information Coauthor Makio Gamoh deceased.