Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays

• DOI: 10.1007/s10157-013-0784-x
• Publication Date: 2013-02-27T01:34:05Z
• Authors: Nahoko Yata; Osamu Uemura; Masataka Honda; Takeshi Matsuyama; Kenji Ishikura; Hiroshi Hataya; Takuhito Nagai; Yohei Ikezumi; Naoya Fujita; Shuichi Ito; Kazumoto Iijima; Mari Saito; Tetsuji Keneko; Teruo Kitagawa
• Keywords: Male; Autoanalysis; Adolescent; Infant; 03 medical and health sciences; 0302 clinical medicine; Asian People; Reference Values; Child, Preschool; Humans; Female; Cystatin C; Child

The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.