Recurrence and graft loss after renal transplantation in adults with IgA vasculitis

• DOI: 10.1007/s10157-016-1336-y
• Publication Date: 2016-09-27T09:02:49Z
• Authors: Mayuko Kawabe; Izumi Yamamoto; Yo Komatsuzaki; Takafumi Yamakawa; Haruki Katsumata; Ai Katsuma; Aki Mafune; Yasuyuki Nakada; Akimitsu Kobayashi; Yudo Tanno; Ichiro Ohkido; Nobuo Tsuboi; Keitaro Yokoyama; Shigeru Horita; Masayoshi Okumi; Hideki Ishida; Hiroyasu Yamamoto; Takashi Yokoo; Kazunari Tanabe
• Keywords: Adult; Male; Time Factors; Graft Survival; Kaplan-Meier Estimate; Allografts; Kidney Transplantation; Methylprednisolone; Immunoglobulin A; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Pulse Therapy, Drug; Recurrence; Risk Factors; Humans; Kidney Failure, Chronic; Female; Tokyo; Immunosuppressive Agents; Retrospective Studies; Tonsillectomy

IgA vasculitis, a rare condition resulting in end-stage renal disease, is a small-vessel vasculitis that affects the kidney in 49-83 % of adults. The reported recurrence rate of IgA vasculitis in renal transplant recipients is 11.5-60 %, leading to graft loss in 0-50 % of these patients. However, limited data are available on recurrence and graft loss after renal transplantation.We evaluated renal transplant recipients seen from 1987 to 2015 at the Jikei University School of Medicine and the Department of Urology, Tokyo Women's Medical University. Using a 1:2 match, 21 patients with IgA vasculitis and 42 controls were selected. The mean post-transplant follow-up was 121 ± 69 months for IgA vasculitis and 147 ± 66 months for the controls.The 15-year patient survival was 100 % in IgA vasculitis and 97.6 % in the controls (p = 0.22). The 5-, 10-, and 15-year graft survival rates were 95.2, 90.5, and 81 % in IgA vasculitis and 100, 90.5, and 88.1 % in the controls, respectively (p = 0.63). The recurrence rate was 28.6 % (6 of 21 cases) and half of them (3 of 6 cases) showed histological activity (ISKDC III). We treated them with methylprednisolone pulse therapy and/or tonsillectomy. None of the recurrence cases lost the allograft.The long-term patient and graft survival of IgA vasculitis in renal transplantation were comparable with the previous reports. The recurrence rate was 28.6 %, but none of the recurrent cases showed allograft loss in this study. We speculate that methylprednisolone pulse therapy and/or tonsillectomy prevent the progression of recurrent IgA vasculitis.