Riboflavin prophylaxis in pediatric and adolescent migraine

• DOI: 10.1007/s10194-009-0142-2
• Publication Date: 2009-07-31T12:40:26Z
• Authors: Maria Condò; Annio Posar; Annalisa Arbizzani; Antonia Parmeggiani
• Keywords: Tolerability; Prophylactic treatment

Migraine is a common disorder in childhood and adolescence. Studies on adults show the effectiveness tolerability of riboflavin migraine prevention, while data children are scarce. This retrospective study reports our experience using for prophylaxis 41 pediatric adolescent patients, who received 200 or 400 mg/day single oral dose 3, 4 6 months. Attack frequency intensity decreased (P < 0.01) during treatment, these results were confirmed follow-up. A large number patients (77.1%) reported that abortive drugs effective controlling ictal events. During follow-up, 68.4% cases had 50% greater reduction attacks 21.0% intensity. Two vomiting increased appetite, respectively, most likely causes unrelated to use riboflavin. In conclusion, seems be well-tolerated, effective, low-cost prophylactic treatment adolescents suffering from migraine.