A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets

• DOI: 10.1007/s10237-017-0966-7
• Publication Date: 2017-10-09T07:06:46Z
• Authors: Jiao Chen; Daphne Weihs; Fred J. Vermolen
• Keywords: Pancreatic Islets

Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response well other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic islets. determined by the mechanical strain energy density cytokines-driven chemotaxis. displacement modeled solving large system ordinary stochastic differential equations where parts result from random walk. The are solved use classical Euler–Maruyama method. In this paper, influence anisotropic stromal extracellular matrix islets on T-lymphocytes different systems investigated. As result, peripheral impedes through changing direction their migration.