Magnetic resonance elastography in nonlinear viscoelastic materials under load

• DOI: 10.1007/s10237-018-1072-1
• Publication Date: 2018-08-27T06:06:02Z
• Authors: Adela Capilnasiu; Myrianthi Hadjich...; Daniel Fovargue; Dharmesh Patel; Ondrej Holub; Lynne Bilston; Hazel Screen; Ralph Sinkus; David Nordsletten
• Keywords: Magnetic Resonance Elastography

Characterisation of soft tissue mechanical properties is a topic increasing interest in translational and clinical research. Magnetic resonance elastography (MRE) has been used this context to assess the tissues vivo noninvasively. Typically, these analyses rely on linear viscoelastic wave equations material from measured dynamics. However, deformations that occur some (e.g. liver during respiration, heart cardiac cycle, or external compression breast exam) can yield loading bias, complicating interpretation stiffness MRE measurements. In paper, it shown how combined knowledge material's rheology state be eliminate bias enable intrinsic (unloaded) properties. Equations are derived utilising perturbation theory Cauchy's motion demonstrate impact periodic steady-state behaviour nonlinear materials. These yields apparent stiffening, softening anisotropy. sensitivity deformation demonstrated an experimental phantom, showing up twofold. From unbiased [Formula: see text] Pa unloaded state, biased increases 9767.5 text]1949.9 under load 34% uniaxial compression. Integrating phantom into novel reconstruction, possible characterise characteristics, eliminating data. The framework introduced phantoms illustrates pathway translated applied complex deforming tissues. This would contribute better assessment employing elastography.