Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients

• DOI: 10.1007/s10238-023-01002-7
• Publication Date: 2023-01-26T18:02:48Z
• Authors: Chuanying Geng; Guangzhong Yang; Huixing Zhou; Huijuan Wang; Yanchen Li; Yun Leng; Zhiyao Zhang; Yuan Jian; Wenming Chen
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Humans; Multiple Myeloma; Prognosis; Retrospective Studies

Abstract Background: The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to evaluate basic activities of daily life, but few studies have evaluated its prognostic value in MM. Methods: We retrospectively enrolled patients with newly diagnosed MM and analyzed the association between the BI and the survival of newly diagnosed MM patients. Results: We totally analyzed 538 patients and found that median overall survival (OS) and progression-free survival (PFS) were significantly shorter in the low BI (≤85) group compared with the high BI (>85) group. Univariate Cox proportional hazards regression analysis showed that the low BI was associated with shorter OS and PFS. It was also confirmed that the low BI was poor prognostic factor for OS and PFS in multivariable analyses. In the propensity score matching analysis, patients with low BI also had shorter OS and PFS. Conclusion: Our study suggested that the low BI was a poor prognostic factor for patients with newly diagnosed MM.