Degradation, Bioactivity, and Osteogenic Potential of Composites Made of PLGA and Two Different Sol–Gel Bioactive Glasses

• DOI: 10.1007/s10439-011-0307-4
• Publication Date: 2011-04-12T14:03:58Z
• Authors: Elzbieta Pamula; Justyna Kokoszka; Katarzyna Cholewa...; Maria Laczka; Lukasz Kantor; Lukasz Niedzwiedzki; Gwendolen C. Reilly; Joanna Filipowska; Wojciech Madej; Malgorzata Kolodz...; Grzegorz Tylko; Anna M. Osyczka
• Keywords: Bioactive Glass; PLGA; Simulated body fluid

We have developed poly(l-lactide-co-glycolide) (PLGA) based composites using sol–gel derived bioactive glasses (S-BG), previously described by our group, as composite components. Two different types were manufactured that contained either S2—high content silica S-BG, or A2—high lime S-BG. The evaluated in the form of sheets and 3D scaffolds. Sheets containing 12, 21, 33 vol.% each glass characterized for mechanical properties, wettability, hydrolytic degradation, surface bioactivity. A2 S-BG rapidly formed a hydroxyapatite layer after incubation simulated body fluid. incorporation increased tensile strength Young's modulus tailored their degradation rates compared to starting compounds. scaffolds ability support growth human bone marrow cells (BMC) MG-63 cells, respectively. Cells grown non-differentiating, osteogenic osteoclast-inducing conditions. Osteogenesis was induced with recombinant BMP-2 dexamethasone, osteoclast formation M-CSF. BMC viability lower at higher content, though specific ALP/cell significantly on PLGA/A2-33 composites. Composites S2 enhanced calcification extracellular matrix BMC, whereas promoted from BMC. osteoblast-like seeded porous maintained secreted collagen calcium throughout Overall, presented data show functional versatility studied indicate potential design wide variety implant materials differing physico-chemical properties biological applications. propose these glass–PLGA may prove excellent orthopedic dental biomaterials supporting remodeling.