Spatial Intracranial Pressure Fields Driven by Blast Overpressure in Rats

• DOI: 10.1007/s10439-024-03544-7
• Publication Date: 2024-06-08T19:01:18Z
• Authors: Carly Norris; Susan F. Murphy; Caiti-Erin Talty; Pamela J. VandeVord
• Keywords: Overpressure

Free-field blast exposure imparts a complex, dynamic response within brain tissue that can trigger cascade of lasting neurological deficits. Full body mechanical and physiological factors are known to influence the body's adaptation this seemingly instantaneous insult, making it difficult accurately pinpoint injury mechanisms. This study examined intracranial pressure (ICP) profile characteristics in rat model as function overpressure magnitude location. Metrics such peak rate change pressure, rise time, ICP frequency were found vary spatially throughout brain, independent magnitude, emphasizing unique spatial fields primary biomechanical component injury. work discusses considerations for finite element models, vitro translational vivo models improve understanding biomechanics during exposure.