Molecular imaging of tumor angiogenesis using αvβ3-integrin targeted multimodal quantum dots

• DOI: 10.1007/s10456-008-9124-2
• Publication Date: 2008-12-08T15:49:58Z
• Authors: Willem J. M. Mulder; Karolien Castermans; Judy R. van Beijnum; Mirjam G. A. oude...; Patrick T. K. Chin; Zahi A. Fayad; Clemens W. G. M. ...; Eric L. Kaijzel; Ivo Que; Gert Storm; Gustav J. Strijkers; Arjan W. Griffioen; Klaas Nicolay
• Keywords: Molecular Imaging; Molecular probe

Molecular imaging of angiogenesis is urgently needed for diagnostic purposes such as early detection, monitoring (angiostatic) therapy and individualized therapy. Multimodality molecular a promising refined technique to study tumor angiogenesis, which has so far been largely unexplored due the lack suitable multimodal contrast agents. Here, we report on application novel alphavbeta3-specific quantum dot-based nanoparticle, optimized both optical magnetic resonance detection angiogenesis. Upon intravenous injection RGD-pQDs in tumor-bearing mice, intravital microscopy allowed angiogenically activated endothelium at cellular resolution with small scanning window limited penetration depth, while was used visualize anatomical throughout entire tumor. Fluorescence whole-body investigation angiogenic activity. Using these dots aforementioned modalities, vasculature readily detected highest activity occurring periphery This nanoparticle may be employed multimodality variety diseases that are accompanied by activation endothelial cells. Furthermore, current technology might developed other pathophysiological processes.