Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients

• DOI: 10.1007/s10461-017-1683-z
• Publication Date: 2017-01-31T13:19:31Z
• Authors: Lewis J. Haddow; Rosanna Laverick; Marina Daskalopoulou; Jeffrey McDonnell; Fiona C. Lampe; Richard Gilson; Andrew Speakman; Andrea Antinori; Pietro Balestra; Tina Bruun; Jan Gerstoft; Lars Nielsen; Anna Vassilenko; Simon Collins; Alison J. Rodger
• Keywords: Neurocognitive; Depression; Cross-sectional study; Health psychology; Outpatient clinic

We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized pen-and-paper neuropsychological tests. NCI was defined as normalized Z score ≤−1 at least 2 out 5 cognitive domains. Participants' mean age 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported decline activities daily living. Prevalence lower those always able afford basic needs (adjusted ratio [aPR] 0.71, 95% confidence interval [CI] 0.54–0.94) or education (aPR 0.72, CI 0.54–0.97) higher severe depressive symptoms 1.53, 1.09–2.14) significant comorbid condition 1.40, 1.03–1.90).