The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma

• DOI: 10.1007/s10495-024-01994-x
• Publication Date: 2024-07-27T06:02:36Z
• Authors: Zhengwei Zhang; Xiaoning Chen; Yapeng Li; Feng Zhang; Zhen Quan; Zhuo Wang; Yang Yang; Wei Si; Yuting Xiong; Jiaming Ju; Yu Bian; Shibo Sun
• Keywords: Anoikis

Anoikis-Related Genes (ARGs) lead to the organism manifesting resistance anoikis and are associated with unfavorable prognostic outcomes across various malignancies.Therefore, it is crucial identify pivotal target genes related in HCC .We found that ARGs were significantly correlated prognosis immune responses HCC. The core gene, SPP1, notably promoted metastasis through both vivo vitro studies. PI3K-Akt-mTOR pathway played a critical role suppression within contexts. Our research unveiled SPP1's enhancing PKCα phosphorylation, which turn activated cascade. Additionally, SPP1 was identified as key regulator of MDSCs Tregs migration, directly affecting their immunosuppressive capabilities.These findings indicate HCC, facilitated evasion by modulating Tregs.