Cell microvesicles during experimental endotoxemia

• DOI: 10.1007/s10517-006-0421-8
• Publication Date: 2007-02-21T14:58:06Z
• Authors: L. D. Zubairova; D. M. Zubairov; I. A. Andrushko; G. Yu. Svintenok; I. G. Mustafin
• Keywords: Microvesicle; Blood clotting

The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them containing ecto-5'-nucleotidase. Biphasic changes in arterial blood clotting time and erythrocyte hemolysis were observed.