Perinatal Hypoxic and Ischemic Damage to the Central Nervous System Causes Changes in the Expression of Connexin 43 and CD38 and ADP-Ribosyl Cyclase Activity in Brain Cells

• DOI: 10.1007/s10517-009-0385-6
• Publication Date: 2009-04-27T23:42:32Z
• Authors: A. B. Salmina; N. A. Malinovskaya; O. S. Okuneva; T. E. Taranushenko; A. A. Fursov; S. V. Mikhutkina; A. V. Morgun; S. V. Prokopenko; L. D. Zykova
• Keywords: Central Nervous System; 0303 health sciences; Brain; ADP-ribosyl Cyclase 1; Immunohistochemistry; Gene Expression Regulation, Enzymologic; Brain Ischemia; Rats; 3. Good health; 03 medical and health sciences; Animals, Newborn; Gene Expression Regulation; Connexin 43; Animals; ADP-ribosyl Cyclase; Hypoxia

The expression of connexin 43 and CD38 and ADP ribosyl cyclase activity in brain cells were studied in rats with experimental hypoxic and ischemic damage to the CNS. Changes in the expression and activity of the enzyme were detected over the course of ischemic injury indicating a possible contribution of NAD(+)-converting activity and NAD(+)-transporting processes to the pathogenesis of acute cerebral ischemic injury.