Tetrapeptide H-Ala-Glu-Asp-Arg-OH Stimulates Expression of Cytoskeletal and Nuclear Matrix Proteins

• DOI: 10.1007/s10517-012-1766-9
• Publication Date: 2012-09-12T04:06:10Z
• Authors: V. Kh. Khavinson; N. S. Lin’kova; V. O. Polyakova; I. M. Kvetnoy; V. V. Benberin; M. M. D’yakonov; Yu. S. Titkov
• Keywords: Nuclear matrix; Tetrapeptide; Matrix (chemical analysis)

Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.