Stimulation of Proliferation and Differentiation of Rat Resident Myocardial Cells with Apoptotic Bodies of Cardiomyocytes

• DOI: 10.1007/s10517-015-2909-6
• Publication Date: 2015-06-01T06:40:56Z
• Authors: A. I. Tyukavin; G. B. Belostotskaya; T. A. Golovanova; M. M. Galagudza; E. A. Zakharov; N. V. Burkova; D. Yu. Ivkin; A. A. Karpov
• Keywords: Heart cells

Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart.