Reconstruction of Ligament and Tendon Defects Using Cell Technologies

• DOI: 10.1007/s10517-017-3660-y
• Publication Date: 2017-02-27T18:00:54Z
• Authors: R. K. Chailakhyan; A. B. Shekhter; S. V. Ivannikov; V. I. Tel’pukhov; D. S. Suslin; Yu. V. Gerasimov; A. M. Tonenkov; A. G. Grosheva; P. V. Panyushkin; I. L. Moskvina; N. N. Vorob’eva; V. N. Bagratashvili
• Keywords: Gelatin; Vicryl

We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.