Effect of MGHPPGP Peptide Administered during the Post-Traumatic Period on Morphometric Parameters of the Neocortex and Hippocampus, Hepatocytes, and Epithelium of the Tongue and Small Intestine in Rats

• DOI: 10.1007/s10517-020-04745-5
• Publication Date: 2020-03-09T08:03:12Z
• Authors: M. Yu. Fleishman; N. Yu. Yakusheva; Yu. B. Malofey; I. V. Tolstenok; A. A. Innokentiev
• Keywords: Neocortex

The effect of glyproline-containing peptide MGHPPGP (Met-Glu-His-Phe-Pro-Gly-Pro) was studied in experiments on male Wistar rats with modeled traumatic brain injury. The peptide was administered intraperitoneally in a dose of 1 mg/kg in 3 h and on days 2, 3, 4, 5 after injury. We evaluated morphometric parameters of the epithelial cells of the tongue, small intestine, and liver cells (AgNOR staining), neuronal layers II and V of the neocortex of the parietal lobe and hippocampal CA1 field (staining with gallocyanin) were evaluated in the post-traumatic period. Traumatic brain injury (TBI) was induced in rats by using the impact model (WDM; weight drop method). MGHPPGP peptide corrected the activity indicators of the nuclear organizer regions in epitheliocytes of the tongue.