Association of the NOS3 Gene Polymorphisms with the Risk of Atopic Dermatitis in Children

• DOI: 10.1007/s10517-021-05155-x
• Publication Date: 2021-04-25T05:08:45Z
• Authors: О. А. Svitich; А. V. Kudryavtseva; Е. S. Slyusareva; Е. О. Kravtsova; Е. А. Meremianina; Е. P. Bystritskaya; V. V. Sobolev; А. I. Ryabtsev; А. B. Potapova; V. V. Zverev
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Gene Frequency; Genotype; Nitric Oxide Synthase Type III; Case-Control Studies; Humans; Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Dermatitis, Atopic

We studied association of polymorphic markers Glu298Asp (rs1799983), C774T (rs1549758), and T786C (rs2070744) of the NOS3 gene with the risk of atopic dermatitis. It was found that T786C polymorphic marker of the NOS3 gene is associated with lower risk of erythematosquamous lichenoid atopic dermatitis. A significant association between the homozygous CC genotype in locus 786 of the NOS3 gene and the development of erythematosquamous atopic dermatitis with lichenification was revealed. The homozygous CC genotype can be considered as a risk factor of erythematosquamous atopic dermatitis with lichenification.