Pro-Gastrin-Releasing Peptide as a Marker of Small Cell Lung Cancer

• DOI: 10.1007/s10517-022-05529-9
• Publication Date: 2022-06-23T06:02:55Z
• Authors: N. V. Lyubimova; A. E. Kuz’minov; A. A. Markovich; A. V. Lebedeva; Yu. S. Timofeev; I. S. Stilidi; N. E. Kushlinskii
• Keywords: 03 medical and health sciences; Lung Neoplasms; 0302 clinical medicine; Gastrin-Releasing Peptide; Phosphopyruvate Hydratase; Biomarkers, Tumor; Chromogranin A; Humans; Small Cell Lung Carcinoma

The serum levels of pro-gastrin-releasing peptide (proGRP), neuron-specific enolase (NSE), and chromogranin A (CgA) were studied in 69 patients with small cell lung cancer and 50 apparently healthy donors. A significant increase of all studied biochemical markers was revealed in small cell lung cancer patients, while the highest diagnostic efficiency was demonstrated by proGRP compared to NSE and CgA. ProGRP is a promising biochemical marker of small cell lung cancer, especially sensitive in patients with distant metastases (in the brain, liver, and bones).