Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging

• DOI: 10.1007/s10522-008-9197-8
• Publication Date: 2008-11-22T02:06:04Z
• Authors: Thore C. Brink; Lloyd Demetrius; Hans Lehrach; James Adjaye
• Keywords: Senescence; Homeostasis; Life span; Metabolic pathway

Individual differences in the rate of aging are determined by efficiency with which an organism transforms resources into metabolic energy thus maintaining homeostatic condition its cells and tissues. This observation has been integrated analytical studies process to derive following principle: The stability regulatory networks, that is ability maintain stable concentrations reactive oxygen species (ROS) other critical metabolites prime determinant life span. a network diversity pathways or degree connectivity genes network. These properties can be empirically evaluated terms transcriptional changes gene expression. We use microarrays investigate age-dependence insulin signaling, oxidative phosphorylation glutathione metabolism mice. Our delineate age tissue specific patterns consistent stability-longevity principle. study, addition, rejects free radical hypothesis postulates production ROS, not stability, determines