Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast

• DOI: 10.1007/s10522-019-09846-x
• Publication Date: 2019-10-28T13:10:58Z
• Authors: Karolina Stępień; Dominik Wojdyła; Katarzyna Nowak; Mateusz Mołoń
• Keywords: Hormesis; Cellular Aging

Curcumin is a biologically active compound of vegetable origin which has hormetic effect. Pro-health and anti-aging properties curcumin have been known for years. The main benefit thought to be its anti-oxidative action. Despite vast amount data confirming age-delaying activity in various groups organisms, so far little discovered about curcumin's impact on cell aging the experimental model Saccharomyces cerevisiae budding yeast. We able demonstrate that significantly increases oxidative stress accelerates replicative chronological yeast cells devoid protection (with SOD1 SOD2 gene deletion) deprived DNA repair mechanisms (RAD52). Interestingly, delays aging, probably through hormesis, wild-type strain BY4741.