Micromechanical properties of hydrogels measured with MEMS resonant sensors

• DOI: 10.1007/s10544-012-9730-z
• Publication Date: 2012-12-17T06:48:39Z
• Authors: Elise A. Corbin; Larry J. Millet; James H. Pikul; Curtis L. Johnson; John G. Georgiadis; William P. King; Rashid Bashir
• Keywords: Microscale chemistry; Indentation; Biocompatibility; Microtechnology; Microsystem

Hydrogels have gained wide usage in a range of biomedical applications because of their biocompatibility and the ability to finely tune their properties, including viscoelasticity. The use of hydrogels on the microscale is increasingly important for the development of drug delivery techniques and cellular microenvironments, though the ability to accurately characterize their micromechanical properties is limited. Here we demonstrate the use of microelectromechanical systems (MEMS) resonant sensors to estimate the properties of poly(ethylene glycol) diacrylate (PEGDA) microstructures over a range of concentrations. These microstructures are integrated on the sensors by deposition using electrohydrodynamic jet printing. Estimated properties agree well with independent measurements made using indentation with atomic force microscopy.