High patient satisfaction with a simplified BRCA1/2 testing procedure: long-term results of a prospective study

• DOI: 10.1007/s10549-018-5000-y
• Publication Date: 2018-10-11T07:56:59Z
• Authors: Martin P. Nilsson; Erik D. Nilsson; Åke Borg; Yvonne Brandberg; Barbro Silfverberg; Niklas Loman
• Keywords: Aged, 80 and over; BRCA2 Protein; 0301 basic medicine; BRCA1 Protein; Salpingo-oophorectomy; Breast Neoplasms; Genetic Counseling; Middle Aged; Patient Acceptance of Health Care; Clinical Trial; 3. Good health; 03 medical and health sciences; Prophylactic Mastectomy; Patient Satisfaction; Mutation; Humans; Female; Genetic Testing; Prospective Studies; Aged; Follow-Up Studies

In the BRCAsearch study, unselected breast cancer patients were prospectively offered germline BRCA1/2 mutation testing through a simplified procedure. The purpose of present study was to evaluate satisfaction with procedure and, furthermore, report on uptake rates prophylactic surgeries among carriers. Pre-test information provided by standardized invitation letter instead in-person genetic counseling. contact counselor for telephone counseling if they felt need that. Mutation carriers telephoned and given time face-to-face post-test appointment. Non-carriers informed about test result letter. One year after results delivered, study-specific questionnaire mailed participants who had consented testing. response rate 83.1% (448 539). A great majority (96.0%) responders content method used providing within 98.7% having pursued 11.1% answered that would have liked receive more oral information. an adjusted logistic regression model, somatic comorbidity (OR 2.56; P = 0.02) born outside Sweden 3.54; 0.01) likely, occupations requiring at least 3 years university or college education 0.37; 0.06) less likely wanting All 11 attended At median follow-up 2 years, salpingo-oophorectomy 100%, mastectomy 55%. Satisfaction very high. Written pre-test has now replaced in our health care region.