Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications

• DOI: 10.1007/s10549-019-05442-2
• Publication Date: 2019-09-18T17:05:41Z
• Authors: Emma H. Allott; Yue Shan; Mengjie Chen; Xuezheng Sun; Susana Garcia-Recio; Erin L. Kirk; Andrew F. Olshan; Joseph Geradts; H. Shelton Earp; Lisa A. Carey; Charles M. Perou; Ruth M. Pfeiffer; William F. Anderson; Melissa A. Troester
• Keywords: Epidemiology; Sequence Analysis, RNA; Gene Expression Profiling; 610; Breast Neoplasms; Genomics; Middle Aged; Immunohistochemistry; name=SDG 3 - Good Health and Well-being; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Age Distribution; 0302 clinical medicine; Biomarkers, Tumor; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; Humans; Female; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being; Age of Onset; Aged

Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or groupings of tumors with shared risk factors. While RNA-based methods including PAM50 have identified well-established clinical subtypes, diagnosis a proxy for subtype are not established molecular and genomic tumor classifications.We evaluated smoothed distributions Carolina Breast Cancer Study cases within immunohistochemistry-based expression categories. Akaike information criterion (AIC) values compared the fit single density versus two-component mixture models. Two-component models estimated proportion early-onset late-onset categories by ER (n = 2860), ESR1 1965). findings were validated using pooled publicly available data 8103).Breast cancers best characterized incidence peaks near 45 65 years, regardless characteristics. However, proportional composition varied Higher ER-protein ESR1-RNA showed greater late age-at-onset. Similarly, shifting age-at-onset distribution, most pronounced found in Basal-like Luminal A, respectively.Bimodal was detected Study, similar to national registry data. Our support fundamental age-defined that persist across Better criteria distinguish could improve understanding etiology contribute prevention efforts.