Premenopausal women with breast cancer in the early post-partum period show molecular profiles of invasion and are associated with poor prognosis

• DOI: 10.1007/s10549-023-06956-6
• Publication Date: 2023-05-10T21:41:28Z
• Authors: Vidya P. Nimbalkar; V. P. Snijesh; Savitha Rajarajan; Annie Alexander; Rohini Kaluve; Rakesh Ramesh; B. S. Srinath; Jyothi S. Prabhu
• Keywords: Menarche

Abstract Purpose Young premenopausal women develop breast cancer (BC) within 5–10 years of the last childbirth, known as post-partum cancers (PPBC), often present with aggressive disease. The exact mechanisms that lead to poor prognosis in these patients are largely unknown. Methods We have evaluated association clinical and reproductive factors BC a cohort ≤ 45 ( N = 155) long-term follow-up. Based on duration since childbirth (LCB), grouped into PPBC1 (LCB 5 years), PPBC2 between 6 10 PPBC3 > NPBC (age-matched nulliparous patients). compared disease-free survival hazard associated recurrence/metastasis groups. RNA sequencing tumor samples was performed from three parous groups n 10), transcriptomic data were analyzed for differentially expressed genes altered pathways. Results Women group had an early menarche late age at first other Survival analysis lymph node-positive tumors showed worse than p 0.015 0.026, respectively). Clustering distinct expression PPBC (E-PPBC) tumors. Pathway revealed upregulation invasive-related pathways along T cell exhaustion, extracellular matrix remodeling, angiogenesis, epithelial-to-mesenchymal transition E-PPBC Conclusion Early is unique subtype features biology. Further research needed accurately project risk recurrence optimal treatment strategies young patients.