The effects of contemporary treatment of DCIS on the risk of developing an ipsilateral invasive Breast cancer (iIBC) in the Dutch population

• DOI: 10.1007/s10549-023-07168-8
• Publication Date: 2023-11-14T17:02:44Z
• Authors: Sena Alaeikhanehshir; Renée S.J.M. Schmitz; Alexandra W. van ...; Frederieke H. van...; Ellen Verschuur; Maartje van Seijen; Michael Schaapveld; Esther H. Lips; Jelle Wesseling
• Keywords: Carcinoma, Intraductal, Noninfiltrating; Epidemiology; Incidence; Carcinoma, Ductal, Breast; Humans; Female; Breast Neoplasms; Neoplasm Recurrence, Local; Mastectomy, Segmental; Mastectomy

Abstract Purpose To assess the effects of contemporary treatment ductal carcinoma in situ (DCIS) on risk developing an ipsilateral invasive breast cancer (iIBC) Dutch female population. Methods Clinical data was obtained from Netherlands Cancer Registry (NCR), a nationwide registry all primary malignancies integrated with PALGA, network and histo- cytopathology Netherlands, women treated for DCIS 2005 to 2015, resulting population-based cohort 14.419 women. Cumulative iIBC incidence assessed associations type subsequent were evaluated by multivariable Cox regression analyses. Results Ten years after diagnosis, cumulative 3.1% (95% CI: 2.6–3.5%) patients conserving surgery (BCS) plus radiotherapy (RT), 7.1% 5.5–9.1) BCS alone, 1.6% 1.3–2.1) mastectomy. associated significantly higher compared + RT during first 5 (HR 2.80, 95% 1.91–4.10%). After follow-up, declined alone group but remained than 1.73, 1.15–2.61). Conclusions Although absolute risks low either or RT, at least 10 diagnosis.