Factors associated with locoregional recurrence after neoadjuvant chemotherapy for breast cancer in a safety-net medical center

• DOI: 10.1007/s10549-025-07668-9
• Publication Date: 2025-03-04T16:05:37Z
• Authors: Danielle Brabender; Deena Hossino; Sean Kim; Margaret Jayich; Lauren Polyakov; David Gomez; Azadeh A. Carr; Stephen F. Sener
• Keywords: Neoadjuvant Therapy; Single Center; Medical record

Abstract Background The management of locally advanced breast cancer poses significant challenges, with contemporary strategies involving an approach that combines systemic and local treatment. current study was performed to validate the clinical impression locoregional recurrences have become increasingly uncommon after standardized multimodal treatment protocol.Please check confirm authors their respective affiliations been correctly identified amend if necessary.All are correct. Methods A retrospective analysis using a single-institution database included clinical, radiographic, pathologic parameters for all non-metastatic non-inflammatory patients treated neoadjuvant chemotherapy (NAC) from 2015 2023. Uni- multivariable analyses were define associations between factors, recurrence, RFS. Results median age 51 years 274 predominantly Hispanic (78%) patients, follow-up 38.1 months. recurrence rates 4% local, 2% regional, 18% distant. Median time surgery 8.2 months regional 9.7 There no in 92 (34%) who had pCR or 85 (31%) radiological complete response NAC. Locoregional > 12 surgery. Five 11 occurred poor NAC (ypT4b). All 6 having adjuvant radiation therapy, only 2 pathologically node-negative (ypN0) post-NAC. Conclusions Favorable responses associated excellent control rates. achieved at safety net medical center similar those reported prospective, randomized trials.