Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

• DOI: 10.1007/s10557-012-6427-8
• Publication Date: 2012-12-07T10:05:48Z
• Authors: João Tomé-Carneiro; Manuel Gonzálvez; Mar Larrosa; María J. Yáñez-Ga...; Francisco J. Garc...; José A. Ruiz-Ros; Francisco A. Tomá...; María T. García-C...; Juan Carlos Espín
• Keywords: Male; Anti-Inflammatory Agents; Down-Regulation; Coronary Artery Disease; Cardiovascular; Coronary artery disease; Clinical trials; Stilbenes; Humans; Pharmacology (medical); Vitis; Pharmacology; Plant Extracts; Middle Aged; 3. Good health; Treatment Outcome; Research Design; Resveratrol; Dietary Supplements; Leukocytes, Mononuclear; Plasminogen activator inhibitor type 1 (PAI-1); Original Article; Female; Adiponectin; Cardiology and Cardiovascular Medicine; Transcription Factors

The grape and wine polyphenol resveratrol exerts cardiovascular benefits but evidence from randomized human clinical trials is very limited. We investigated dose-depending effects of a resveratrol-containing supplement on stable patients with coronary artery disease (CAD) treated according to currently accepted guidelines for secondary prevention disease.In triple-blind, randomized, placebo-controlled, one-year follow-up, 3-arm pilot trial, 75 stable-CAD received 350 mg/day placebo, extract (grape phenolics plus 8 mg resveratrol) or conventional lacking during 6 months, double dose the following months. Changes in circulating inflammatory fibrinolytic biomarkers were analyzed. Moreover, transcriptional profiling genes peripheral blood mononuclear cells (PBMCs) was explored using microarrays functional gene expression analysis.After 1 year, contrast placebo groups, group showed an increase anti-inflammatory serum adiponectin (9.6 %, p = 0.01) decrease thrombogenic plasminogen activator inhibitor type (PAI-1) (-18.6 0.05). In addition, key inflammation-related transcription factors predicted be significantly activated inhibited, 27 extracellular-space acting involved inflammation, cell migration T-cell interaction signals presenting downregulation (p < 0.05) PBMCs. No adverse detected relation study products.Chronic daily consumption nutraceutical could exert current evidence-based standards, by increasing adiponectin, preventing PAI-1 inhibiting atherothrombotic