In situ fabrication of a microporous bacterial cellulose/potato starch composite scaffold with enhanced cell compatibility

• DOI: 10.1007/s10570-014-0220-8
• Publication Date: 2014-03-07T09:19:58Z
• Authors: Jingxuan Yang; Xiangguo Lv; Shiyan Chen; Zhe Li; Chao Feng; Huaping Wang; Yuemin Xu
• Keywords: Bacterial Cellulose

Microporous bacterial cellulose/potato starch (BC/PS) composites composed of a compact upper surface and transparent lower surface were fabricated by an in situ method by adding PS into the culture medium. The special structure formation mechanism was explored. Compared with original BC, a locally oriented surface morphology was observed when the concentration of PS in the culture media was above 1.0 %. Many more free spaces were made after modification with pore size reaching 40 μm. An obvious cell ingrowth tendency was observed on the porous surface of BC/PS composites as the starch content increased, while most of muscle-derived cells could only proliferate on the surface of original BCs. In vivo implantation showed the transparent fibrous lower side of BC/PS composites was much easier for neovascularization, and no obvious sign of inflammation was observed.