Clinical characteristics, treatment, and long-term outcome of patients with brain metastases from thyroid cancer

• DOI: 10.1007/s10585-023-10208-8
• Publication Date: 2023-05-23T04:03:16Z
• Authors: Ladislaia Wolff; Ariane Steindl; Petar Popov; Karin Dieckmann; Brigitte Gatterbauer; Georg Widhalm; Anna Sophie Berghoff; Matthias Preusser; Markus Raderer; Barbara Kiesewetter
• Keywords: Medullary Thyroid Cancer; Surgical oncology

Brain metastases (BM) in patients with thyroid cancer (TC) are rare an incidence of 1% for papillary and follicular, 3% medullary up to 10% anaplastic TC (PTC, FTC, MTC ATC). Little is known about the characteristics management BM from TC. Thus, we retrospectively analyzed histologically verified radiologically identified Vienna Metastasis Registry. A total 20/6074 included database since 1986 had 13/20 were female. Ten 8 PTC, one ATC. The median age at diagnosis was 68 years. All but symptomatic a singular BM. Synchronous primary found 6 patients, while time 13 years PTC (range 1.9-24), 4 FTC 2.1-41) 22 patient. overall survival months 1.8-57), 26 3.9-188), 12 3 ATC In conclusion, development exceedingly most common presentation single lesion. While generally constitute poor prognostic factor, individual experience long-term following local therapy.