Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases

• DOI: 10.1007/s10585-024-10279-1
• Publication Date: 2024-03-29T03:01:45Z
• Authors: Sophia Leduc; Ha-Linh Nguyen; François Richard; Gitte Zels; Amena Mahdami; Maxim De Schepper; Marion Maetens; Anirudh Pabba; Joris Jaekers; Emily Latacz; Ali Bohlok; Evy Vanderheyden; Thomas Van Brussel; Bram Boeckx; Rogier Schepers; Diether Lambrechts; Luc Dirix; Denis Larsimont; Sophie Vankerckhove; Valerio Lucidi; Baki Topal; Imane Bachir; Vincent Donckier; Giuseppe Floris; Peter Vermeulen; Christine Desmedt
• Keywords: Surgical oncology; Hematology

Abstract Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection (BCLM) is associated prolonged survival. However, there currently no validated marker to identify these patients. The interactions between the metastatic cells microenvironment result two main histopathological growth patterns (HGP): replacement (r-HGP), characterized by a direct contact hepatocytes, desmoplastic (d-HGP), which fibrous rim surrounds tumor cells. who underwent BCLM, r-HGP worse postoperative prognosis than d-HGP. Here, we aim at unraveling biological differences HGP within ten presenting both same metastasis. transcriptomic analyses reveal overexpression genes involved cell cycle, DNA repair, vessel co-option motility while angiogenesis, wound healing, several immune processes were found overexpressed d-HGP LM. Understanding biology LM could open avenues refine treatment BC