Synthesis of glycyrrhetic acid derivatives

• DOI: 10.1007/s10600-008-9012-4
• Publication Date: 2008-08-20T15:20:40Z
• Authors: J.-P. Yong; J.-W. Wang; H. A. Aisa; L.-J. Liu
• Keywords: Proton NMR

11-Deoxyglycyrrhetinic acid (DGA) (2) was produced by Clemmensen reduction of the C-11 carbonyl of 18β-glycyrrhetic acid (GA) (1). Four derivatives of GA and DGA (3a–3d) were synthesized. Their structures were elucidated using spectral data (IR, mass, 1H, 13C NMR).