Synthesis of rupestonic acid amide derivatives and their in vitro activity against type A3 and B flu virus and herpes simplex I and II

• DOI: 10.1007/s10600-008-9050-y
• Publication Date: 2008-09-30T06:04:19Z
• Authors: J.-P. Yong; H. A. Aisa
• Keywords: Amide

Derivatives of rupestonic acid (5a-e) were synthesized and evaluated preliminarily at the National Center for Drug Screening (PRC) for antiviral activity against type A(3) and B flu virus and HSV-I and HSV-II in order to improve the biological activity of rupestonic acid. It was found that compound 5b was more active than rupestonic acid against type A(3) flu virus.