Antituberculosis activity of glycosides from Stevia rebaudiana and hybrid compounds of steviolbioside and pyridinecarboxylic acid hydrazides

• DOI: 10.1007/s10600-011-9779-6
• Publication Date: 2011-02-07T04:23:38Z
• Authors: R. R. Sharipova; I. Yu. Strobykina; G. G. Mordovskoi; R. V. Chestnova; V. F. Mironov; V. E. Kataev
• Keywords: Stevia rebaudiana

Stevioside and steviolbioside, glycosides from Stevia rebaudiana Bertoni, in addition to hybrid compounds synthesized from steviolbioside and the antituberculosis drug isoniazid and its isomer nicotinic acid hydrazide exhibited moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro (MIC = 7.5, 3.75, 5, and 10 μg/mL, respectively).