Synthesis of 1-amidoalkyl-2-naphthols via three-component condensation of 2-naphthol, aldehydes, and amides/urea

• DOI: 10.1007/s10600-012-0200-x
• Publication Date: 2012-05-12T14:50:04Z
• Authors: M. Wang; Y. Liang; T. T. Zhang; J. J. Gao
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and amides/urea using tin tetrachloride as catalyst at 80aC without solvent is described. The structures of the new compounds were characterized by IR, 1H NMR, and 13C NMR spectra and by elemental analysis. The advantages of the new method were good yields (45–97%), short reaction times (0.1–4 h), simple work-up, inexpensive catalyst, and the diversity of the method.