Anti-colon carcinoma cell activity of ginsenosides from the acid hydrolysate of Panax ginseng

• DOI: 10.1007/s10600-013-0453-z
• Publication Date: 2013-02-16T01:17:18Z
• Authors: Wei Li; Jian Yuan Yin; Zhong Yi Cong; Ying Liu; Ying Zhang; Yan Yan Li; Qin Meng
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

Six dammarane ginsenosides, 20(R)-dammar-25-ethoxy-3β,12β,20-triol (1), 3β,6α,12β-triol22,23,24,25,26,27-hexanordammaran-20-one (2), dammar-(E)-20(22)-ene-3β,12β,25-triol (3), 20(S)-dammar-3β,12β,20,25-tetrol (4), and 20(R)-protopanaxadiol (5), 20(R)-protopanaxatriol (6), were isolated from the acid hydrolysate of Panax ginseng. Compound 1 was only mentioned in a patent literature, and there is no spectroscopic data elsewhere. This paper is the first to elucidate the structure of compound 1 on the basis of spectroscopic evidence. The biological activities of compounds 1–6, crude ginsenosides, and the ginsenoside-hydrolysate were determined in human colon carcinoma cell. Compounds 1–3 and the ginsenoside-hydrolysate exhibited anti-human colon carcinoma cell activity, with IC50 of 66.1, 72.4, 50.1, and 25.7 μg/mL, respectively.