Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones

• DOI: 10.1007/s10600-013-0570-8
• Publication Date: 2013-06-12T01:10:00Z
• Authors: G. P. Mrug; S. P. Bondarenko; V. P. Khilya; M. S. Frasinyuk
• Keywords: 01 natural sciences; 0104 chemical sciences

A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.