Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity

• DOI: 10.1007/s10600-020-03071-6
• Publication Date: 2020-06-04T08:04:02Z
• Authors: Qiu-Fen Hu; Ling-Min Liao; Hai-Tao Huang; Yong Xu; Jin Wang; Wei-Song Kong; Qi-Li Mi; Min Zhou; Guang-Yu Yang; Chun-Man Song
• Keywords: Isoquinoline; Mosaic virus; Ranunculaceae

Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one (1) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one (2) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The two compounds showed weak anti-TMV activity with inhibition rates of 28.9 and 32.6%. These rates are close to that of positive control.