Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity

• DOI: 10.1007/s10600-020-03072-5
• Publication Date: 2020-06-03T14:31:32Z
• Authors: Dian Luo; Na Lv; Li-Jun Zhu; Ling-Min Liao; Yong Xu; Jin Wang; Wei-Song Kong; Hai-Tao Huang; Min Zhou; Guang-Yu Yang; Qiu-Fen Hu; Xiao-Xi Si
• Keywords: Isoquinoline; Ranunculaceae

Two new (1 and 2), together with two known (3 and 4), isoquinoline alkaloids were isolated from the whole plants of Thalictrum cirrhosum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their antirotavirus activity. The results revealed that compounds 2 exhibited high antirotavirus activity with a therapeutic index (TI) value of 19.3. This value is close to that of positive control (TI value 20.4). Compounds 1, 3, and 4 also exhibited potent antirotavirus activity with TI value above 10.