Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies

• DOI: 10.1007/s10654-020-00688-3
• Publication Date: 2020-10-30T17:04:01Z
• Authors: Piet A. van den B...; Regina G. Ziegler; Molin Wang; Tao Hou; Ruifeng Li; Hans-Olov Adami; Claudia Agnoli; Leslie Bernstein; Julie E. Buring; Yu Chen; Avonne E. Connor; A. Heather Eliassen; Jeanine M. Genkinger; Gretchen Gierach; Graham G. Giles; Gary G. Goodman; Niclas Håkansson; Vittorio Krogh; Loic Le Marchand; I-Min Lee; Linda M. Liao; M. Elena Martinez; Anthony B. Miller; Roger L. Milne; Marian L. Neuhouser; Alpa V. Patel; Anna Prizment; Kim Robien; Thomas E. Rohan; Norie Sawada; Leo J. Schouten; Rashmi Sinha; Rachael Z. Stolze...; Lauren R. Teras; Shoichiro Tsugane; Kala Visvanathan; Elisabete Weiderpass; Kami K. White; Walter C. Willett; Alicja Wolk; Anne Zeleniuch-Ja...; Stephanie A. Smit...
• Keywords: Adult; 570; 610; Breast Neoplasms; Weight Gain; Body Mass Index; Cohort Studies; EARLY-LIFE; 03 medical and health sciences; MASS INDEX; REGRESSION-MODELS; 0302 clinical medicine; Risk Factors; Estrogen receptor; Humans; Prospective Studies; METAANALYSIS; Aged; 2. Zero hunger; Weight change; Body Weight; PROGESTERONE; Body weight; Middle Aged; 3. Good health; Body height; ESTROGEN; PHYSICAL-ACTIVITY; POSTMENOPAUSAL WOMEN; Premenopause; Receptors, Estrogen; Cohort studies; GROWTH; SEX-HORMONES; Female; Breast neoplasms; Menopause; Meta-Analysis

Abstract Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. prediagnostic of premenopausal postmenopausal BC overall ER/PR status subtypes were investigated in a pooled analysis 20 prospective cohorts, including 36,297 cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet other factors. We estimated dose–response relationships tested nonlinear associations restricted cubic splines. Height showed positive, linear (6–7% RR increase per 5 cm increment), with stronger receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated risk, positively—and nonlinearly—associated (especially women who never used hormone replacement therapy). This primarily observed Early adult BMI (at 18–20 years) inverse, (21% 11% decrease kg/m 2 , respectively) receptor-negative Adult weight gain since years positively subtypes, leaner early adulthood. Women heavier adulthood generally had reduced independent later gain. Positive height, (adult) BMI, substantially versus negative Premenopausal but (mostly subtypes). Inverse seemed BC.