Breast and ovarian cancer risk management in a French cohort of 158 women carrying a BRCA1 or BRCA2 germline mutation: patient choices and outcome

• DOI: 10.1007/s10689-012-9539-1
• Publication Date: 2012-06-18T15:42:24Z
• Authors: Pascale This; Anne de la Rochef...; Alexia Savignoni; Marie Christine F...; Anne Tardivon; Fabienne Thibault; Séverine Alran; Virgine Fourchotte; Alfred Fitoussi; Benoit Couturaud; Sylvie Dolbeault; Remy J. Salmon; Brigitte Sigal-Za...; Bernard Asselain; Dominique Stoppa-...
• Keywords: Adult; BRCA2 Protein; Ovarian Neoplasms; BRCA1 Protein; Ovariectomy; Breast Neoplasms; Middle Aged; 3. Good health; Cohort Studies; Salpingectomy; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Humans; Female; Genetic Predisposition to Disease; France; Germ-Line Mutation; Mastectomy; Aged; Follow-Up Studies

Description of the various modalities of breast and ovarian cancer risk management, patient choices and their outcome in a single-center cohort of 158 unaffected women carrying a BRCA1 or BRCA2 germline mutation. Between 1998 and 2009, 158 unaffected women carrying a BRCA1 or BRCA2 gene mutation were prospectively followed. The following variables were studied: general and gynecological characteristics, data concerning any prophylactic procedures, and data concerning the outcome of these patients. Median age at inclusion was 37 years and median follow-up was 54 months. Among the 156 women who received systematic information about prophylactic mastectomy, 5.3 % decided to undergo surgery within 36 months after disclosure of genetic results. Prophylactic salpingo-oophorectomy was performed in 68 women. Among women in whom follow-up started between the ages of 40 and 50 years, prophylactic salpingo-oophorectomy was performed, within 24 months after start of follow-up, in 83.7 and 52 % of women with BRCA1 and BRCA2 mutations, respectively. Twenty four women developed breast cancer. Ovarian cancer was detected during prophylactic salpingo-oophorectomy in two women (2.9 %). In this cohort of French women carrying BRCA1/2 mutations, prophylactic mastectomy was a rarely used option. However, good compliance with prophylactic salpingo-oophorectomy was observed. This study confirms the high breast cancer risk in these women.