FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation

• DOI: 10.1007/s10753-018-0729-3
• Publication Date: 2018-02-09T00:48:48Z
• Authors: Jun-yan Li; Nan Wang; Mir Hassan Khoso; Cheng-bin Shen; Meng-ze Guo; Xin-xin Pang; De-shan Li; Wen-fei Wang
• Keywords: Fibroblast Growth Factors; Inflammation; Lipopolysaccharides; 0303 health sciences; 03 medical and health sciences; MAP Kinase Signaling System; Interleukin-1beta; Humans; Cell Line; Interleukin-10

Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.