Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis

• DOI: 10.1007/s10787-024-01439-6
• Publication Date: 2024-02-26T07:02:11Z
• Authors: Chenyu Zhao; Yunyuan Yu; Guangrong Yin; Chao Xu; Jiahao Wang; Liangliang Wang; Gongyin Zhao; Su Ni; Haoxing Zhang; Baojun Zhou; Yuji Wang
• Keywords: Sulfasalazine

Ferroptosis has been reported to play a role in rheumatoid arthritis (RA). Sulfasalazine, common clinical treatment for ankylosing spondylitis, also exerts pathological influence on the progression of including induced ferroptosis fibroblast-like synoviocytes (FLSs), which result perturbated downstream signaling and development RA. The aim this study was investigate underlying mechanism so as provide novel insight