Resting-State Oscillatory Activity in Autism Spectrum Disorders

• DOI: 10.1007/s10803-011-1431-6
• Publication Date: 2011-12-29T13:25:09Z
• Authors: Lauren Cornew; Timothy P. L. Rob...; Lisa Blaskey; J. Christopher Edgar
• Keywords: Cerebral Cortex; Male; Brain Mapping; Adolescent; Magnetoencephalography; Brain Waves; 03 medical and health sciences; 0302 clinical medicine; Biological Clocks; Child Development Disorders, Pervasive; Humans; Female; Child

Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.