DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders

• DOI: 10.1007/s10803-020-04792-x
• Publication Date: 2021-01-04T15:03:34Z
• Authors: Michelle T. Siu; Sarah J. Goodman; Isaac Yellan; Darci T. Butcher; Maryam Jangjoo; Daria Grafodatskaya; Rageen Rajendram; Youliang Lou; Rujun Zhang; Chunhua Zhao; Rob Nicolson; Stelios Georgiades; Peter Szatmari; Stephen W. Scherer; Wendy Roberts; Evdokia Anagnostou; Rosanna Weksberg
• Keywords: dNaM; Oxytocin receptor; Neurotypical

Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes.