In vivo comparison of braided (Accero) and laser-cut intracranial stents (Acclino, Credo): evaluation of vessel responses at subacute and mid-term follow-up in a rabbit model

• DOI: 10.1007/s10856-020-06460-z
• Publication Date: 2020-12-03T10:03:24Z
• Authors: Ruben Mühl-Bennin...; Toshiki Tomori; Stefanie Krajewski; Philipp Dietrich; Andreas Simgen; Umut Yilmaz; Christoph Brochha...; Mara Kießling; Wolfgang Reith; Giorgio Cattaneo
• Keywords: Neointima; Thrombogenicity; Digital subtraction angiography

Abstract This study aimed to investigate in vivo two stent technologies, with particular emphasis on thrombogenicity and inflammatory vessel remodeling processes. The micro-stents tested this were developed for intracranial aneurysm treatment. In our twelve, New Zealand white rabbits divided into groups: 18 laser-cut stents (LCS) braided (BS) impanated without admiration of antiplatelet medication. Three implanted each animal the common carotid artery, subclavian abdominal aorta. Digital subtraction angiography was performed before after implantation at follow-up visualization occurring In-stent thromboembolism or stenosis. Stents explanted histopathological examination different timepoints, 3 28 days. Angiographically neither in-stent thrombosis nor stenosis both groups seen. There a progressive increase diameter, which more pronounced BS than LCS. We detected higher number thrombi adherent foreign material day BS. On 3, neointima absent, whereas complete formation observed 28. no significant difference between regarding thickness neointima. model enabled evaluation blood reactions technologies. Differences dimension tissue around Histological analysis assessment thrombotic reactions, representing an important complementary result long-term studies.