Sol–gel based synthesis and biological properties of zinc integrated nano bioglass ceramics for bone tissue regeneration

• DOI: 10.1007/s10856-020-06478-3
• Publication Date: 2021-01-20T10:06:56Z
• Authors: Pragyan Paramita; Murugesan Ramacha...; Srinivasan Narash...; Selvamurugan Naga...; Dinesh Kumar Sukumar; Tze-Wen Chung; Moorthi Ambigapathi
• Keywords: Biomaterial

Abstract Bone is a flexible and electro active tissue that vulnerable to various traumatic injuries. The self-healing of damaged bone towards reconstruction limited due the lack proper niche compliances. Nevertheless, classical grafting techniques like autograft/allograft for repair pose challenges bacterial infections donor-site morbidity with unsatisfactory outcomes. use appropriate biomaterial osteogenic potential can meet these challenges. In this regard, bioactive glass ceramics widely used as filler or graft material because its bonding affinity leading applications without challenge post implant infections. Hence, current study aimed at addressing potentiality zinc (Zn) doped bioglass nano-scale advantages repair. Since, Zn has been demonstrated have not only antibacterial property but also stimulatory effect on osteoblasts differentiation, mineralization by enhancing genes expression. view these, present focused sol–gel synthesis pysico-chemical characterization Zinc-doped nanoparticles (Zn-nBGC) analyzing biological implications. surface morphological physiochemical characterizations using SEM, EDX, FT-IR XRD analysis shown increased area Zn-nBGC particles providing great platform biomolecular interaction, cytocompatibility, cell proliferation differentiation. obtaining hydroxy apatite groups initiated in vitro lineage formation. involved cellular actions strengthen ceramic application. Hence finding suggests better engineering application preventing post-operative infection.