Investigation of Mg–xLi–Zn alloys for potential application of biodegradable bone implant materials

• DOI: 10.1007/s10856-021-06516-8
• Publication Date: 2021-04-06T19:03:00Z
• Authors: Jingan Li; Panyu Zhou; Liguo Wang; Yachen Hou; Xueqi Zhang; Shijie Zhu; Shaokang Guan
• Keywords: Elongation

Abstract Implant therapy after osteosarcoma surgery is a major clinical challenge currently, especially the requirements for mechanical properties, degradability of implants, and their inhibition residual tumor cells. Biodegradable magnesium (Mg) alloy as medical bone implant material has full advantages huge potential development space. Wherein, Mg–lithium (Li) based alloy, an ultra-light good properties implants under certain conditions, both Mg Li have inhibitory effects on Therefore, Mg–Li expected to be applied in materials supporting inhibiting cells simultaneously. In this contribution, Mg– x Li–Zinc (Zn) series alloys ( = 3 wt%, 6 9 wt%) were prepared study influence different elements contents structure biosafety was also evaluated. Our data showed that yield strength, tensile elongation as-cast Li–Zn higher than those Mg–Zn alloy; can kill (MG-63) concentration-dependent manner, wherein Mg–3Li–Zn (x Mg–6Li–Zn promoted proliferation osteoblasts (MC3T3) at concentration Li. summary, our demonstrated could potentially orthopedic its excellent multi-functions.